Key Principles of Pharmacology
An overview display of the different components, playing a role in a medicines effect in the body, is given in the following graphs:
Figure.1: Schematic representation of the different components acting in human pharmacology and their classification. (adapted from ‘Introduction to Pharmacokinetics’, J. Scott Daniels, Vanderbilt Univ Medical Center, 2012).
When determining the effect a medicine has, the time course from administration to excretion plays an important role as does the interaction between dose administered, pharmacokinetics (influence on concentration) and pharmacodynamics (influence on the effect). The following schematic ‘From PK to PD’ depicts this interrelation.
Figure. 2: Schematic quantitative representation of the interaction between PK – PD – time – effect after administration of a medicine (adapted from ‘Introduction to Pharmacokinetics’,
J. Scott Daniels, Vanderbilt Univ Medical Center, 2012)