Principles of New Trial Designs and their Practical Implications

5. Further Reading

  • Clinical Trials Planned with an Adaptive Design (2007): here

  • Chow SC, Chang M. Adaptive design methods in clinical trials - a review. Orphanet J Rare Dis. 3(11) May 2008: here

  • I. Judson, J. Verweij, H. Gelderblom, et al. Results of a randomised phase III trial (EORTC 62012) of single agent doxorubicin versus doxorubicin plus ifosfamide as first line chemotherapy for patients with advanced or metastatic soft tissue sarcoma: a survival study by the EORTC Soft Tissue and Bone Sarcoma Group.

  • Sydes MR, Parmar MK, James ND, et al. Issues in applying multi-arm multi-stage methodology to a clinical trial in prostate cancer: the MRC STAMPEDE trial. Trials. 10 (39) Jun 2009: here

  • Kairalla JA, Coffey CS, Thomann MA, Muller KE. Adaptive trial designs: a review of barriers and opportunities. Trials. 13 (145) Aug 2012: here

  • Cytel Webinar for EastĀ®SurvAdapt. October 28, 2010: here