3. Randomised Controlled Clinical Trial Designs

3.1. Factorial Design

In factorial design, it is assumed that there is no interaction between medicines.

Factorial design attempts to evaluate two interventions compared to a control in one trial.

Each participant receives two different treatments: x and y; x and control; y and control; control and control.

Image explaining factorial design. Each participant receives two different treatments: x & y; x & con; y & cont; cont & cont