Blinding in Clinical Trials
An open-label trial is one in which no blinding is used and all parties are aware of the allocation of participants to treatment groups.
Open-label trials may be used:
- For surgical procedures*.
- When changes in lifestyle are required.
- When endpoints are objective and cannot be interpreted in different ways.
- For studies in life-threatening situations.
- In post-marketing surveillance.
- When ethical considerations do not permit blinding.
- When no control group can be used.