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      1. Ethics
      2. Clinical Trials in Non-Standard Situations

      Clinical Trials in Non-Standard Situations

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      • The following resources present relevant infromation on this topic:

        • Recommendations for the design of small population clinical trials - PMC (nih.gov)
        • IRDiRC Publications & Recommendations – IRDiRC
        • Clinical trial designs for rare diseases: Studies developed and discussed by the International Rare Cancers Initiative - European Journal of Cancer (ejcancer.com)
        • The patient’s view on rare disease trial design – a qualitative study | Orphanet Journal of Rare Diseases | Full Text (biomedcentral.com)
        • Non-Inferiority Clinical Trials | FDA
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