Principles of New Trial Designs and their Practical Implications

5. Further Reading

• Clinical Trials Planned with an Adaptive Design (2007): Available at: Reflection Paper on Methodological Issues in Confirmatory Clinical Trials Planned with an Adaptive Design (europa.eu)
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• Chow SC, Chang M. Adaptive design methods in clinical trials - a review. Orphanet J Rare Dis. 3(11) May 2008: Available at: 1750-1172-3-11.pdf (biomedcentral.com) 
  
  
• I. Judson, J. Verweij, H. Gelderblom, et al. Results of a randomised phase III trial (EORTC 62012) of single agent doxorubicin versus doxorubicin plus ifosfamide as first line chemotherapy for patients with advanced or metastatic soft tissue sarcoma: a survival study by the EORTC Soft Tissue and Bone Sarcoma Group.
  
  
• Sydes MR, Parmar MK, James ND, et al. Issues in applying multi-arm multi-stage methodology to a clinical trial in prostate cancer: the MRC STAMPEDE trial. Trials. 10 (39) Jun 2009: Available at: 1745-6215-10-39.fm (nih.gov)
  
  
• Kairalla JA, Coffey CS, Thomann MA, Muller KE. Adaptive trial designs: a review of barriers and opportunities. Trials. 13 (145) Aug 2012: Available at: 1745-6215-13-145.pdf (biomedcentral.com)
  
  
• Cytel Webinar for East®SurvAdapt. October 28, 2010: Available at: d:\cyrus-office\working\East-SurvAdapt-Webinar.dvi (cytel.com)